Project Biohacking Newsletter: 8/19/2025

Hey Everyone,

This issue cuts straight to the fat that matters most—visceral fat. Hidden deep in the belly, it drives aging, inflammation, and disease… But the right peptides, science, and strategies can shrink it and reset your metabolism.

Let’s go!

Table of Contents

• Introduction

• Curated Content—Science & Links on Tesamorelin

  • The Research Without the Noise

• Announcements

  • Project Biohacking Coaching is here!

  • Join The Health Truth Seeker Circle - connect with …

• Newsletter Feature:

• Tesamorelin for Fat Loss & Longevity

• From Around The Web

• 🔮 Next Issue Preview

  • Why Women Lose Their Curves

• 🔚 Outro & Final Thoughts

Introduction

Imagine stepping on the scale, seeing the number drop, but realizing the fat you’ve lost isn’t from your arms or legs—it’s the dangerous fat packed around your organs. That’s what Tesamorelin does. Unlike crash diets that strip away muscle and leave you weaker, this peptide specifically mobilizes visceral fat while protecting lean mass.

Researchers first developed it for HIV patients suffering from lipodystrophy, but now biohackers are paying attention. Why? Because Tesamorelin doesn’t just change how you look—it changes how your metabolism functions at the deepest level.

Today, we’ll uncover how it works, how people are using it, and what kind of transformations it produces.

Curated Content—Science & Links on Tesamorelin

The Research Without the Noise

• Tesamorelin Clinical Data
  In a phase III clinical trial, patients receiving Tesamorelin experienced a 15–20% reduction in visceral fat over six months, while placebo groups saw no change. Lean muscle mass was preserved, which sets Tesamorelin apart from standard fat-loss interventions.
  Quick Insight:

  • Tesamorelin doesn’t just make you smaller—it reshapes metabolism to burn the fat that matters most.

• Visceral Fat & Longevity
  A landmark study in The Lancet followed over 360,000 participants and found that waist-to-hip ratio and belly fat predicted mortality more strongly than BMI. In other words, where fat is stored matters more than total body weight.
  Quick Insight:

  • The tape measure around your waist tells more about your lifespan than the scale ever will.

• Growth Hormone Dynamics
  A review in Endocrine Reviews explains how growth hormone and IGF-1 regulate fat distribution, muscle maintenance, and energy balance. Tesamorelin mimics youthful GH signaling, describing why it selectively reduces visceral fat.
  Quick Insight:

  • This peptide doesn’t just reduce fat—it mimics the hormonal patterns of youth to restore metabolic flexibility.

Announcements

If you have not listened to Crrow777 Radio’s Episode #637, check it out below. And share, share, share on social media! This is information they don’t want you to post; please share the knowledge!! 👇🏻

Project Biohacking Coaching is here!

I’m excited to introduce biohacking coaching on our platform. If you signed up but did not get an email, please check your spam folder.

These packages are designed for those eager to explore new possibilities. If you are ready to get started, please use the code Crrow50 to receive a 50% discount on the Biohacking Foundations Coaching Package. 🤩 

Join The Health Truth Seeker Circle - connect with like-minded truth-seekers exploring natural healing⚕️

The dates for next month's meetup will be announced in a few weeks, along with additional details. Sign up now so you don’t miss it!

Affiliate Content (aka: how I keep the lights on and my peptides cold)
Occasionally, I recommend products I love, and if you buy through my links, I may earn a small commission. It doesn’t cost you extra, but it does help fund my n=1 experiments… like seeing how many peptides I can fit in one fridge drawer. So, this week it’s Pique Life.👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻👇🏻

Newsletter Feature:

Tesamorelin for Fat Loss & Longevity

(Educational purposes only—not medical advice)

Most people consider fat to be simply “stored energy.” But certain fat, visceral fat, is the most dangerous kind. It’s a killer!!

Visceral fat accumulates around internal organs at rates 2–3 times faster than subcutaneous fat in adults over 40. This intra-abdominal adipose tissue secretes 30% more inflammatory cytokines than peripheral fat deposits, directly accelerating cellular aging through chronic low-grade inflammation.

Enter Tesamorelin, a peptide developed initially to treat lipodystrophy in HIV patients in 2010. The FDA has approved it under the name Egrifta. Clinical trials demonstrated 15-20% reductions in visceral adipose tissue over 26 weeks, while lean muscle mass remained stable or increased by 2-4%.

Today, biohackers are taking notice because it targets visceral fat explicitly while increasing muscle. That’s a rare combination.

How Tesamorelin Works

• GHRH Analog: This man-made 44-amino acid peptide closely resembles the natural growth hormone-releasing hormone, sharing 98%.

• Growth Hormone Boost: Subcutaneous administration increases endogenous GH secretion by 180-220% within 30 minutes, peaking at 60-90 minutes post-injection.

• Fat Mobilization: Elevated GH stimulates IGF-1 production (increases of 40-60% observed in studies), which activates hormone-sensitive lipase and accelerates lipolysis rates by 25-35%.

• Visceral Fat Selectivity: Unlike broad-spectrum GH secretagogues, tesamorelin demonstrates preferential mobilization of intra-abdominal fat through enhanced beta-3 adrenergic receptor sensitivity in visceral adipocytes.

Example Protocol (Educational Use Only)

• Dose: 1-2 mg subcutaneous injection once daily (typical starting dose: 1 mg for individuals under 180 lbs, 2 mg for those above).

• Timing: Administer 2-3 hours after the last meal, preferably 30-60 minutes before sleep to synchronize with natural nocturnal GH pulses.

• Cycle Length: 12-26 weeks produces measurable visceral fat reduction based on DEXA scan data from clinical studies.

• Stacking:

  • It synergistically combines with ipamorelin (100-300 mcg) to extend GH release duration and reduce potential desensitization.

  • It combines with tesofensine (0.25-0.5 mg) to improve appetite regulation by inhibiting norepinephrine and dopamine reuptake.

  • Support protocols include 500-1000 mg NAD+ precursors, 2-3g omega-3 fatty acids daily, and progressive resistance training 3-4x weekly.

(Rotate injection sites across abdomen, thighs, and arms following sterile technique with 29-31 gauge insulin syringes.)

Safety & Considerations

• Side Effects: Peripheral edema affects 8-12% of users, joint stiffness occurs in 15-18%, increased appetite is reported by 22-28%, and carpal tunnel-like symptoms occur in 5-7% of cases.

• Contraindications: Active malignancy, uncontrolled diabetes (HbA1c >8.5%), pregnancy, or severe cardiac dysfunction.

• Lab Monitoring: Track IGF-1 levels (target: upper-normal range 200-300 ng/mL), fasting glucose (<100 mg/dL), and HbA1c (<6.5%) every 8-12 weeks during treatment.

The Bottom Line

Clinical data support tesamorelin as the only FDA-approved peptide specifically targeting visceral adiposity. When combined with structured resistance training and intermittent fasting protocols, users report 10-25% reductions in waist circumference within 16-20 weeks.

Have you considered how visceral fat accumulation might be limiting your longevity goals?

Read more on visceral fat in my blog post: Why Women Lose Their Curves with Age + How to get them back

From Around The Web

🌟 Want that “you just stepped out of a time machine” kind of glow? The Glow Protocol is like biohacking your way back to radiant skin, stronger hair, and unstoppable energy. Hit play and see the magic. 👇

@awakenwithlexy

One week into GLOW and my body is already responding. I’m seeing changes in my skin, energy, and gut. This isn’t hype — it’s real support,... See more

🔮 Next Issue Preview

🔚 Outro & Final Thoughts

That wraps up another deep dive into the science—and strategy—of smarter biohacking.

Every week, we uncover the latest research, protocols, and real-life results so you can make informed, empowered decisions for your health and longevity. Whether you’re here for the latest on peptides, longevity hacks, or community support, remember: sustainable change comes from curiosity, experimentation, and connection.

If today’s content fired you up:

• Share the newsletter with a fellow health explorer

• Hit reply and let me know what excited you most (or what you want covered next)

• Explore 1:1 coaching or personalized protocols here → Coaching

Stay sharp, challenge the status quo, and keep hacking toward your best self.

Until next time,
– Jeff
Founder, Project Biohacking
https://www.projectbiohacking.com/ 

Disclaimer: I’m here to share what I’ve learned, not to replace your doctor. Always check with a qualified healthcare provider before trying anything new. And yes, peptides are often for research use only; please don’t turn your kitchen into a chemistry lab without supervision.